/central nervous system germinoma

central nervous system germinoma

Rare Disease

MONDO:0002999

Also Known As

central nervous system germinomacentral nervous system germinoma (disease)germinoma of CNSgerminoma of central nervous systemgerminoma of the CNSgerminoma of the central nervous systemintracranial germinoma

Definition

A malignant germ cell tumor arising from the central nervous system. It is composed of uniform cells resembling primitive germ cells. These cells have large, vesicular nuclei, prominent nucleoli and a clear, glycogen-rich cytoplasm. Additional features are lymphoid or lymphoplasmacytic infiltrates and, less frequently, scattered syncytiotrophoblastic giant cells. (Adapted from WHO)