/nut midline carcinoma

nut midline carcinoma

Rare Disease

MONDO:0005563

Also Known As

Midline carcinoma of children and Young adults with NUT rearrangementNMCNUT Midline carcinomaNUT carcinomacarcinoma with t(15;19)(q13;p13.1) translocationnuclear protein in testis midline carcinomaNUT midline carcinoma of the head and neck

Definition

A rare, highly aggressive and lethal carcinoma that affects children and young adults. It arises from midline epithelial structures, most commonly the head, neck, and mediastinum. It is a poorly differentiated carcinoma and is characterized by mutations and rearrangement of the NUT gene. A balanced translocation t(15;19) is present that results in the creation of a fusion gene involving the NUT gene, most commonly BRD4-NUT fusion gene.