Cryoglobulinemia is a type of vasculitis that is caused by abnormal proteins (antibodies) in the blood called 'cryoglobulins.' At cold temperatures, these proteins become solid or gel-like, which can block blood vessels and cause a variety of health problems. Many people affected by this condition will not experience any unusual signs or symptoms. When present, symptoms vary but may include breathing problems; fatigue; glomerulonephritis ; joint or muscle pain; purpura ; Raynaud's phenomenon ; skin death; and/or skin ulcers. In some cases, the exact underlying cause is unknown; however, cryoglobulinemia can be associated with a variety of conditions including certain types of infection; chronic inflammatory diseases (such as autoimmune disease); and/or cancers of the blood or immune system. Treatment varies based on the severity of the condition, the symptoms present in each person and the underlying cause.
Comprehensive, easy-to-understand information about this condition
Checking for content...
No external resources available.
autoimmune disease, multisystem, infantile-onset
MONDO:0000213
autoimmune disorder of endocrine system
MONDO:0000569
autoimmune disorder of exocrine system
MONDO:0000586
autoimmune disease of ear, nose and throat
MONDO:0000587
autoimmune disorder of gastrointestinal tract
MONDO:0000588
autoimmune disorder of musculoskeletal system
MONDO:0000589