/granular cell tumor

granular cell tumor

Rare Disease

MONDO:0006235

Also Known As

Abrikossoff tumorAbrikossoff tumourAbrikossoff's tumorAbrikossoff's tumourgranular cell myoblastomagranular cell neoplasmgranular cell nerve sheath tumorgranular cell nerve sheath tumourgranular cell schwannomagranular cell tumorgranular cell tumor (morphologic abnormality)granular cell tumour (morphologic abnormality)granular cell tumor NOS (morphologic abnormality)granular cell tumour NOS (morphologic abnormality)neoplasm of granular cellAbrikosoff's granulous cell tumorAbrikosoff's granulous cell tumourAbrikosoff's tumorAbrikosoff's tumourAbrikosov's tumorAbrikosov's tumourAbrikosov’s tumorAbrikosov’s tumourGCTgiant granulocellular Abrikosov's tumorgiant granulocellular Abrikosov's tumourmalignant variant of Abrikosov's tumormalignant variant of Abrikosov's tumour

Definition

An unusual benign or malignant neoplasm characterized by the presence of neoplastic large polygonal cells with granular, eosinophilic cytoplasm which contains abundant lysosomes. It was originally thought to be a tumor originating from muscle cells and was named granular cell myoblastoma. Subsequent studies have suggested a derivation from Schwann cells. It affects females more often than males and it usually presents as a solitary mass. A minority of patients have multiple tumors. It can arise from many anatomic sites including the posterior pituitary gland, skin, oral cavity, esophagus, stomach, heart, mediastinum, and breast.