/medulloblastoma

medulloblastoma

Rare Disease

MONDO:0007959

Also Known As

brain medulloblastomacerebellar medulloblastomacerebellum embryonal neoplasmmedulloblastomamedulloblastoma, autosomal recessive, autosomal dominant, somatic mutationmedulloblastoma, desmoplastic, autosomal recessive, autosomal dominant, somatic mutationmedulloblastoma, malignantmedulloblastoma, somaticmedulloblastomasCNS PNETCPNETMDBinfratentorial primitive neuroectodermal tumorinfratentorial primitive neuroectodermal tumourlocalised primitive neuroectodermal tumourlocalized primitive neuroectodermal tumormedulloblastoma with extensive nodularitymedulloblastoma, desmoplastic

Definition

A malignant, invasive embryonal neoplasm arising from the cerebellum. It occurs predominantly in children and has the tendency to metastasize via the cerebrospinal fluid pathways. Signs and symptoms include truncal ataxia, disturbed gait, lethargy, headache, and vomiting. There are four histologic variants: classic medulloblastoma, large cell/anaplastic medulloblastoma, desmoplastic/nodular medulloblastoma, and medulloblastoma with extensive nodularity.