/tropical spastic paraparesis

tropical spastic paraparesis

Rare Disease

MONDO:0008039

Also Known As

HAM/TSPHTLV-1-associated myelopathy/tropical spastic paraparesisHTLV-associated myelopathyHuman T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesisHuman T-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesisTSPham/TSPtropical spastic paralysistropical spastic paraplegiaHTLV-1 associated myelopathy/tropical spastic paraparesisHuman T-cell leukaemia virus type 1 associated myelopathy/tropical spastic paraparesisHuman T-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesisfamilial spastic paraparesis, HTLV-1-associatedhammyelopathy, HTLV-1-associatedtropical spastic paraparesis (formerly)

Definition

Tropical spastic paraparesis is a chronic systemic immune-mediated inflammatory myeloneuropathy, more frequently reported in women than in men, that usually presents in adulthood with slowly progressive spastic paraparesis of the lower limbs, bladder and bowel dysfunction, and sensory disturbances in the lower extremities (e.g. paresthesia and dysesthesia) and that is associated with a human T-cell lymphotropic virus type 1 (HTLV-1) infection.