/thrombophilia due to activated protein C resistance

thrombophilia due to activated protein C resistance

Rare Disease

MONDO:0008560

Also Known As

thrombophilia 2 due to activated protein C resistancethrombophilia due to activated protein C resistanceAPC resistanceActivated Protein C resistancePccf deficiencyProc cofactor deficiencyTHPH2resistance, APCthrombophilia 5thrombophilia due to ACTIVATED PROTEIN C resistancethrombophilia due to Factor 5 Leidenthrombophilia due to deficiency of Activated Protein C cofactorthrombophilia, susceptibility to, due to factor V Leiden

Definition

A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.