/tricho-dento-osseous syndrome

tricho-dento-osseous syndrome

Rare Disease

MONDO:0008592

Also Known As

TDOTDO syndromeTRICHODENTOOSSEOUS syndromeTricho Dento Osseous Syndrometrichodontoosseous syndromeTDO syndrome 1Tricho-dento-osseous syndrome 1enamel hypoplasia and hypocalcification with associated strikingly curly hairkinky or curly hair, dolichocephaly, enamel hypoplasia, increased dental caries, radial dense bones, and brittle nails

Definition

Tricho-dento-osseous dysplasia (TDO) belongs to the ectodermal dysplasias and is characterized by curly/kinky hair at birth, enamel hypoplasia with discolouration and molar taurodontism, increased overall bone mineral density (BMD) and increased thickness of the cortical bones of the skull.