/Cushing syndrome due to macronodular adrenal hyperplasia

Cushing syndrome due to macronodular adrenal hyperplasia

Rare Disease

MONDO:0009049

Also Known As

ACTH-independent Cushing syndromeACTH-independent macronodular adrenal hyperplasiaprimary bilateral macronodular adrenal hyperplasiaACTH-independent macronodular adrenocortical hyperplasiaAIMAHMMADadrenocorticotropic hormone-independent macronodular adrenal hyperplasiacorticotropin-independent macronodular adrenal hyperplasiamassive macronodular adrenocortical diseaseprimary macronodular adrenal hyperplasia

Definition

A rare adrenal Cushing syndrome characterized by bilateral benign adrenal macronodules (>1 cm) that potentially produce autonomously variable levels of cortisol excess. Although in most cases are ACTH-independent, non-suppressed ACTH levels have been described.