/growth delay due to insulin-like growth factor I resistance

growth delay due to insulin-like growth factor I resistance

Rare Disease

MONDO:0010038

Also Known As

growth delay due to insulin-like growth factor I resistanceresistance to IGF-1IGF-1 resistanceIGF-I resistanceIGF1RESSomatomedin end-organ insensitivity toSomatomedin, end-organ insensitivity toSomatomedin-C, resistance toSomatomedin-c resistance toinsulin-like Growth Factor I, resistance to, due to increased binding Proteininsulin-like growth factor 1 resistance toinsulin-like growth factor I, resistance to

Definition

Growth delay due to IGF-I resistance is characterized by variable intrauterine and postnatal growth retardation and elevated serum IGF-I levels. Addition features include variable degrees of intellectual deficit, microcephaly and dysmorphism (broad nasal bridge and tip, smooth philtrum, thin upper and everted lower lips, short fingers, clinodactyly, wide-set nipples and pectus excavatum).