/gastrointestinal stromal tumor

gastrointestinal stromal tumor

Rare Disease

MONDO:0011719

Also Known As

GANTGISTGastrointestinal Stromal Tumorsgantgastrointestinal stromal neoplasmgastrointestinal stromal sarcomagastrointestinal stromal tumorgastrointestinal stromal tumor (gist)gastrointestinal stromal tumor, familial, isolated casesgastrointestinal stromal tumor, isolated casesgastrointestinal stromal tumour (gist)giststromal tumor of gastrointestinal tractstromal tumour of gastrointestinal tractgastrointestinal stromal tumorsgastrointestinal stromal tumours

Definition

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal (GI) tract, typically presenting in adults over the age of 40 (mean age 63), and only rarely in children, in various regions of the GI tract, most commonly the stomach or small intestine but also less commonly in the esophagus, appendix, rectum and colon. GISTs can be asymptomatic or present with various non-specific signs, depending on the location and size of tumor, such as loss of appetite, anemia, weight loss, fatigue, abdominal discomfort or fullness, nausea, vomiting, as well as an abdominal mass, blood in stool, and intestinal obstruction. GISTs can also be seen in familial syndromes such as Carney triad and neurofibromatosis type 1.