Hypotrichosis-osteolysis-periodontitis-palmoplantar keratoderma syndrome is an extremely rare ectodermal dysplasia syndrome characterized by hypotrichosis universalis with mild to severe scarring alopecia, acro-osteolysis, onychogryphosis, thin and tapered fingertips, periodontitis and caries leading to premature teeth loss, linear or reticular palmoplantar keratoderma and erythematous, scaling, psoriasis-like skin lesions on arms and legs. Lingua plicata and ventricular tachycardia have also been observed.
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ADULT syndrome
MONDO:0007072
autosomal dominant palmoplantar keratoderma and congenital alopecia
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ameloonychohypohidrotic syndrome
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ankyloblepharon-ectodermal defects-cleft lip/palate syndrome
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anonychia with flexural pigmentation
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Böök syndrome
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