/hereditary spastic paraplegia 25

hereditary spastic paraplegia 25

Rare Disease

MONDO:0011992

Also Known As

SPG25autosomal recessive spastic paraplegia 25autosomal recessive spastic paraplegia type 25autosomal recessive spastic paraplegia-disc herniation syndromehereditary spastic paraplegia type 25Disc herniation with spastic paraplegia, autosomal recessivespastic paraplegia 25spastic paraplegia 25, autosomal recessivespinal disc herniation with autosomal recessive spastic paraplegiaspinal disk herniation with autosomal recessive spastic paraplegia

Definition

Autosomal recessive spastic paraplegia type 25 (SPG25) is a rare, complex type of hereditary spastic paraplegia characterized by adult-onset spastic paraplegia associated with spinal pain that radiates to the upper or lower limbs and is related to disk herniation (with minor spondylosis), as well as mild sensorimotor neuropathy. The SPG25 phenotype has been mapped to a locus on chromosome 6q23-q24.1.