/immunodeficiency due to a late component of complement deficiency

immunodeficiency due to a late component of complement deficiency

Rare Disease

MONDO:0015700

Also Known As

deficiency of complement of terminal pathwayimmunodeficiency due to C5 to C9 component complement deficiencyimmunodeficiency due to a C5 to C9 component complement deficiencyterminal complement pathway deficiency

Definition

A genetic deficiency of any membrane attack complex (MAC, also known as terminal component complex (TCC)) component of the complement system (C5, C6, C7, C8, C9). Deficiencies of the terminal complement pathway results in a predisposition to infections, such as invasive meningococcal disease or disseminated gonococcal infection.