/diffuse astrocytoma

diffuse astrocytoma

Rare Disease

MONDO:0016686

Also Known As

WHO grade II astrocytomaastrocytoma, diffuseastrocytoma, diffuse, malignantdiffuse astrocytomagrade II astrocytic neoplasmgrade II astrocytic tumorgrade II astrocytic tumourgrade II astrocytomafibrillary astrocytoma (histologic variant)gemistocytic astrocytoma (histologic variant)low-grade diffuse astrocytomaprotoplasmic astrocytoma (histologic variant)

Definition

A low-grade (WHO grade II) astrocytic neoplasm. It is characterized by diffuse infiltration of neighboring central nervous system structures. These lesions typically affect young adults and have a tendency for progression to anaplastic astrocytoma and glioblastoma. Based on the IDH genes mutation status, diffuse astrocytomas are classified as IDH-mutant, IDH-wildtype, and not otherwise specified.