T-B- severe combined immunodeficiency (SCID) is a group of rare monogenic primary immunodeficiency disorders characterized by a lack of functional peripheral T and B lymphocytes, resulting in recurrent early-onset severe respiratory viral, bacterial or fungal infections, diarrhea and failure to thrive. Hypersensitivity to ionizing radiation is a characteristic feature of some of its sub-types.
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recombinase activating gene 1 deficiency
MONDO:0000572
recombinase activating gene 2 deficiency
MONDO:0000573
janus kinase-3 deficiency
MONDO:0005511
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency
MONDO:0007064
short-limb skeletal dysplasia with severe combined immunodeficiency
MONDO:0008704
combined immunodeficiency with skin granulomas
MONDO:0009306