/chromophobe renal cell carcinoma

chromophobe renal cell carcinoma

Rare Disease

MONDO:0017885

Also Known As

chromophobe adenocarcinomachromophobe carcinomachromophobe carcinoma of kidneychromophobe carcinoma of the kidneychromophobe cell carcinoma of kidneychromophobe cell carcinoma of the kidneychromophobe renal cell adenocarcinomachromophobe renal cell cancerchromophobe renal cell carcinomakidney chromophoberenal cell carcinoma, chromophobe cellrenal cell carcinoma, chromophobe typeCHRCCCRCCChRCC

Definition

Chromophobe renal cell carcinoma is a rare subtype of renal cell carcinoma, originating from the intercalating cells of the collecting ducts and macroscopically manifesting as a well-circumscribed, highly lobulated, solid tumor that is usually diagnosed at an early stage. It is frequently asymptomatic, or may present with nonspecific symptoms, such as weight loss, fever or fatigue. The classic presentation observed in renal tumors (hematuria, flank pain and palpable mass) is occasionally observed and usually indicates an advanced stage of the disease. It is most frequently sporadic however, several familial cases, associated with Birt-Hogg DubC) syndrome, have been described.