Spastic paraplegia-Paget disease of bone syndrome is an extremely rare, complex form of hereditary spastic paraplegia characterized by a slowly progressive spastic paraplegia (with increased muscle tone, decreased strength in the anterior tibial muscles and hyperreflexia in the lower extremities with Babinski sign) presenting in adulthood, associated with Paget disease of the bone. Cognitive decline, dementia and myopathic changes at muscle biopsy have not been reported.
Comprehensive, easy-to-understand information about this condition
Checking for content...
spastic paraplegia-epilepsy-intellectual disability syndrome
MONDO:0008439
spastic paraplegia-nephritis-deafness syndrome
MONDO:0008440
spastic paraplegia-neuropathy-poikiloderma syndrome
MONDO:0008442
spastic paraplegia-precocious puberty syndrome
MONDO:0008443
hereditary spastic paraplegia 17
MONDO:0010043
hereditary spastic paraplegia 29
MONDO:0012334