acute megakaryoblastic leukemia

Rare Disease

MONDO:0018872

Also Known As

AMKLAML M7FAB M7acute M7 myeloid leukaemiaacute M7 myeloid leukemiaacute megakaryoblastic leukaemia (FAB type M7)acute megakaryoblastic leukemiaacute megakaryoblastic leukemia (FAB type M7)acute megakaryoblastic leukemia, FAB M7acute megakaryocytic leukaemiaacute megakaryocytic leukemiaacute megakaryocytic leukemiasacute myeloid leukaemia M7acute myeloid leukemia M7leukemia, megakaryocytic, malignantmegakaryocytic myelosisthrombocytic leukaemiathrombocytic leukemiaacute myeloblastic leukaemia type 7acute myeloblastic leukemia type 7megakaryocytic leukaemiamegakaryocytic leukemia

Definition

Acute megakaryoblastic leukemia (AMKL) is a form of acute myeloid leukemia (AML) that occurs predominantly in childhood and particularly in children with Down syndrome (DS-AMKL). Nonspecific symptoms may be irritability, weakness, and dizziness while specific symptoms include pallor, fever, mucocutaneous bleeding, hepatosplenomegaly, neurological manifestations and rarely lymphadenopathy. Acute panmyelosis with myelofibrosis may also be associated with AMKL. In contrast to DS-AMKL (around 80 % survival), non-DS-AMKL is an AML subgroup associated with poor prognosis.