/isolated congenital anonychia

isolated congenital anonychia

Rare Disease

MONDO:0019211

Also Known As

isolated anonychiaautosomal recessive nonsyndromic congenital nail disorder-4congenital anonychianonsyndromic congenital nail disorder, 4

Definition

Isolated congenital anonychia is characterized by nail abnormalities ranging from onychodystrophy (dystrophic nails) to anonychia (absence of nails). Onychodystrophy-anonychia has been described in at least four generations of a family with male-to-male transmission, suggesting autosomal dominant transmission. Anonychia has been described in approximately less than 20 cases; it is likely to be transmitted as an autosomal recessive trait. Total anonychia congenita, in which all the fingernails and toenails are absent, may have an autosomal dominant inheritance pattern.