/aggressive NK-cell leukemia

aggressive NK-cell leukemia

Rare Disease

MONDO:0019470

Also Known As

ANKCLNK cell leukaemiaNK cell leukemiaNK-cell LGL leukaemiaNK-cell LGL leukemiaNK-cell large granular lymphocyte leukaemiaNK-cell large granular lymphocyte leukemiaNK-cell leukaemiaNK-cell leukemiaaggressive NK-cell leukaemia (morphologic abnormality)aggressive NK-cell leukemiaaggressive NK-cell leukemia (morphologic abnormality)aggressive NK-cell leukemia/lymphomaaggressive NK-cell lymphomalarge granular lymphocyte leukemia, NK-cell typeleukaemia (disease) of natural killer cellleukemia (disease) of natural killer cellnatural Killer cell leukaemianatural Killer cell leukemianatural killer cell leukaemianatural killer cell leukaemia (disease)natural killer cell leukemianatural killer cell leukemia (disease)ANKLaggressive NK cell leukaemiaaggressive NK cell leukemiaaggressive natural killer cell leukaemiaaggressive natural killer cell leukemia

Definition

A rare, highly aggressive, Epstein-Barr virus-associated leukemia, also known as aggressive NK-cell leukemia/lymphoma; it may represent the leukemic counterpart of nasal type extranodal NK/T-cell lymphomas. It affects primarily teenagers and young adults. It is characterized by the systemic proliferation of NK cells in the peripheral blood, bone marrow, liver, and spleen.