/hereditary von Willebrand disease

hereditary von Willebrand disease

Rare Disease

MONDO:0019565

Also Known As

vascular haemophiliavascular hemophiliavon Willebrand diseasevon Willebrand disordervon Willebrand's-Jurgens' diseasevon Willebrand-Jurgens diseasecongenital von willebrand's diseasehereditary von Willebrand diseasehereditary von Willebrand disease (hereditary or acquired)vascular pseudohemophiliavon Willebrand-Jrgens diseasecongenital von willebrand diseasevon Willebrand's disease

Definition

Hereditary von Willebrand disease (VWD) is a hereditary bleeding disorder caused by a genetic anomaly leading to quantitative, structural or functional abnormalities of the Willebrand factor (von Willebrand factor; VWF). Two major groups of VWF deficiency have been defined: quantitative and partial (type 1) or total (type 3), and qualitative (type 2) with several subtypes (2A, 2B, 2M, 2N).