/malignant dysgerminomatous germ cell tumor of ovary

malignant dysgerminomatous germ cell tumor of ovary

Rare Disease

MONDO:0020538

Also Known As

dysgerminomatous germ cell cancer of ovarydysgerminomatous germ cell cancer of the ovarymalignant ovarian dysgerminomamalignant dysgerminomatous germ cell tumor of the ovarymalignant dysgerminomatous germ cell tumour of the ovary

Definition

Malignant dysgerminomatous germ cell tumor of ovary is the most common form of malignant germ cell tumor of ovary, arising from germ cells in the ovary, usually presenting during adolescence with pelvic mass, fever, vaginal bleeding, and acute abdomen and is characterized by bilaterality (around 10% of cases), association with dysgenetic gonads (5 to 10% of cases), elevated serum lactate dehydrogenase (LDH) and human chorionic gonadotrophin (hCG) (in the presence of syncitiotrophoblasts). Malignant dysgerminomatous germ cell tumor of ovary responds well to chemotherapy, potentially sparing patients from infertility and early mortality.