/ovarian granulosa cell tumor

ovarian granulosa cell tumor

MONDO:0023283

Also Known As

granulosa cell neoplasm of ovarygranulosa cell neoplasm of the ovarygranulosa cell tumor of ovarygranulosa cell tumor of the ovarygranulosa cell tumour of ovarygranulosa cell tumour of the ovaryovarian granulosa cell neoplasmovarian granulosa cell tumorovary granulosa cell tumorovary granulosa cell tumourGCT of the ovaryadult granulosa cell tumor of the ovaryadult granulosa cell tumour of the ovarygranulosa theca cell tumorgranulosa theca cell tumor of the ovarygranulosa theca cell tumourgranulosa theca cell tumour of the ovary

Definition

A granulosa-stromal cell tumor that arises from the ovary. It is characterized by the presence of granulosa cells that comprise at least ten percent of the cellular population. The granulosa cells are often found in a background that contains theca and fibrous cells. There are two major subtypes recognized, adult and juvenile granulosa cell tumor. Clinically, patients may present with an abdominal mass. Symptoms depend on the patient's age. The most important indicator of prognosis is tumor stage. Age over forty years at the time of the initial diagnosis, large tumor size, bilaterality, cellular atypia, and increased mitotic activity are factors indicating a potentially aggressive clinical course and relative poor prognosis.