/tenosynovial giant cell tumor, diffuse type

tenosynovial giant cell tumor, diffuse type

Rare Disease

MONDO:0024686

Also Known As

TGCTTSGCTTenosynovial Giant Cell Tumordiffuse giant cell neoplasm of Tenosynoviumdiffuse giant cell neoplasm of tendon sheathdiffuse giant cell neoplasm of the Tenosynoviumdiffuse giant cell tumor of Tenosynoviumdiffuse giant cell tumor of tendon sheathdiffuse giant cell tumor of the Tenosynoviumdiffuse giant cell tumour of Tenosynoviumdiffuse giant cell tumour of tendon sheathdiffuse giant cell tumour of the Tenosynoviumdiffuse tenosynovial giant cell neoplasmdiffuse tenosynovial giant cell tumordiffuse tenosynovial giant cell tumourpigmented villonodular synovitistenosynovial giant cell tumor, diffuse typevillous tenosynovitisdiffuse pigmented villonodular synovitisdiffuse-type GCTdiffuse-type giant cell tumordiffuse-type giant cell tumourlocalised pigmented villonodular synovitislocalized pigmented villonodular synovitistenosynovial giant cell tumortenosynovial giant cell tumor diffuse typetenosynovial giant cell tumorstenosynovial giant cell tumourtenosynovial giant cell tumour diffuse typetenosynovial giant cell tumoursvillonodular synovitis

Definition

A locally aggressive, diffusely infiltrating tumor, arising in the tendon sheath. It is composed of synovial-like mononuclear cells, hemosiderin-laden macrophages, foam cells, and inflammatory cells. Multinucleated osteoclast-like giant cells are usually present, although in a minority of cases they may be absent or rare. It predominantly affects young adults. Symptoms include joint swelling, pain, and joint effusion.