Any ectodermal dysplasia syndrome in which the cause of the disease is a variation in the CTSC gene. Variations in the CTSC gene can result in (1) Papillon-Lefevre syndrome (PLS) characterized by palmoplantar keratoderma, severe periodontitis affecting deciduous and permanent dentitions, and premature loss of dentition, (2) Haim-Munk syndrome (HMS) with additional features of arachnodactly, acroosteolysis, pesplanus, and onychogryphosis, (3) aggressive periodontitis 1 (AP1) characterized by severe and protracted gingival infections, leading to tooth loss. All three phenotypes are associated with autosomal recessive inheritance.
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ADULT syndrome
MONDO:0007072
autosomal dominant palmoplantar keratoderma and congenital alopecia
MONDO:0007083
ameloonychohypohidrotic syndrome
MONDO:0007095
ankyloblepharon-ectodermal defects-cleft lip/palate syndrome
MONDO:0007124
anonychia with flexural pigmentation
MONDO:0007131
Böök syndrome
MONDO:0007207