/acute monocytic leukemia

acute monocytic leukemia

Rare Disease

MONDO:0007896

Also Known As

monocytic leukaemiamonocytic leukemiaAML M5acute monoblastic leukaemia and acute monocytic leukaemiaacute monoblastic leukemia and acute monocytic leukemiaacute monocytic leukaemia (FAB M5B)acute monocytic leukaemia (FAB M5b)acute monocytic leukaemia without mention of remissionacute monocytic leukemiaacute monocytic leukemia (FAB M5B)acute monocytic leukemia (FAB M5b)acute monocytic leukemia without mention of remissionacute monocytic leukemia, FAB M5acute monocytic leukemia, morphologyacute monocytic leukemia, morphology (morphologic abnormality)leukemia, monocytic, malignantmonocytic leukemia, acuteAML-M5acute monoblastic leukaemiaacute monoblastic leukemiaacute monoblastic/monocytic leukaemiaacute monoblastic/monocytic leukemiaacute myeloblastic leukaemia type 5acute myeloblastic leukemia type 5leukemia, acute monocytic

Definition

Acute monoblastic leukemia (AML-M5), is one of the most common subtypes of acute myeloid leukemia (AML) that is either comprised of more than 80% of monoblasts (AML-M5a) or 30-80% monoblasts with (pro)monocytic differentiation (AML-M5b). AML-M5 presents with asthenia, pallor, fever, and dizziness. Specific features of AML-M5 include hyperleukocytosis, propensity for extramedullary infiltrates, coagulation abnormalities including disseminated intravascular coagulation and neurological disorders. Leukemia cutis and gingival infiltration can also be seen. A characteristic translocation observed in AML-M5 is t(9;11).