/acute promyelocytic leukemia

acute promyelocytic leukemia

Rare Disease

MONDO:0012883

Also Known As

AML M3AML with t(15;17)(q22;q12)AML with t(15;17)(q22;q12);(PML/RARalpha) and variantsAPLAPMLAPML - acute promyelocytic leukaemiaAPML - acute promyelocytic leukemiaFAB M3acute myeloblastic leukaemia 3acute myeloblastic leukaemia type 3acute myeloblastic leukemia 3acute myeloblastic leukemia type 3acute myeloid leukaemia M3acute myeloid leukaemia with t(15;17)(q22;q12);(PML/RARalpha) and variantsacute myeloid leukemia M3acute myeloid leukemia with t(15;17)(q22;q12);(PML/RARalpha) and variantsacute promyelocytic leukaemia with PML-raraacute promyelocytic leukaemia with t(15;17)(q22;q12); PML-raraacute promyelocytic leukaemia with t(15;17)(q22;q12); PML/raraacute promyelocytic leukemiaacute promyelocytic leukemia with PML-raraacute promyelocytic leukemia with t(15;17)(q22;q12); PML-raraacute promyelocytic leukemia with t(15;17)(q22;q12); PML/raraleukemia, acute promyelocytic, somaticpromyelocytic leukaemiapromyelocytic leukemialeukemia, acute promyelocytic

Definition

An aggressive form of acute myeloid leukemia (AML), characterized by arrest of leukocyte differentiation at the promyelocyte stage, due to a specific chromosomal translocation t(15;17) in myeloid cells. APL manifests with easy bruising, hemorrhagic diathesis and fatigue.