/HELLP syndrome

HELLP syndrome

Rare Disease

MONDO:0008585

Also Known As

hemolysis, elevated liver enzymes, low platelets in pregnancyhemolysis-elevated liver enzymes-low platelet count syndromehemolysis-elevated liver enzymes-low platelets syndromePEE1PREECLAMPSIA/eclampsia 1PREG1hemolysis, elevated liver enzymes, and low platelet counthemolysis, elevated liver enzymes, lowered plateletshypertension, pregnancy-inducedtoxaemia of pregnancytoxemia of pregnancy

Definition

A life-threatening condition that can potentially complicate pregnancy. It is named for 3 features of the condition: H emolysis, E levated L iver enzyme levels, and L ow P latelet levels. It typically occurs in the last 3 months of pregnancy (the third trimester) but can also start soon after delivery. A wide range of non-specific symptoms may be present in women with HELLP syndrome. Symptoms may include fatigue; malaise; fluid retention and excess weight gain; headache; nausea and vomiting; pain in the upper right or middle of the abdomen; blurry vision; and rarely, nosebleed or seizures. The cause of HELLP syndrome is not known, but certain risk factors have been associated with the condition. It is most common in women with preeclampsia or eclampsia. If not diagnosed and treated quickly, HELLP syndrome can lead to serious complications for the mother and baby.The main treatment is to deliver the baby as soon as possible, even if premature. Treatment may also include medications needed for the mother or baby, and blood transfusion for severe bleeding problems.