/Ewing sarcoma/peripheral primitive neuroectodermal tumor of bone

Ewing sarcoma/peripheral primitive neuroectodermal tumor of bone

Rare Disease

MONDO:0021123

Also Known As

Ewing sarcoma/peripheral primitive neuroectodermal tumor of boneEwing's sarcoma/peripheral primitive neuroectodermal tumor of boneEwing's sarcoma/peripheral primitive neuroectodermal tumour of bonebone tissue Ewing sarcoma/peripheral primitive neuroectodermal tumorbone tissue Ewing sarcoma/peripheral primitive neuroectodermal tumour

Definition

A spectrum of malignant tumors arising from the bone and characterized morphologically by the presence of small round cells. Ewing sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor. Ewing sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities. Pain and the presence of a mass are the most common clinical symptoms.