A distinct form of Acute myeloid leukemia (AML) in which this chromosomal anomaly is found de novo or in therapy-related AML cases, and is characterized by frequent extramedullary involvement (mainly hepatomegaly, splenomegaly, lymphadenopathies, cutaneous infiltration, but also gum, bone, central nervous system, testicles involvement), severe coagulation disorder (disseminated intravascular coagulopathy or primary fibrinolysis) and poor prognosis. Morphologically, a blast population with a myelomonocytic stage of differentiation is observed.
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childhood acute myeloid leukemia
MONDO:0004996
acute monocytic leukemia
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acute promyelocytic leukemia
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acute myeloid leukemia with t(8;21)(q22;q22) translocation
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acute myeloid leukemia by FAB classification
MONDO:0015667
inherited acute myeloid leukemia
MONDO:0017893